N-{6-Oxo-5-[(pyridin-3-yl)methyl]-1,6-dihydropyrimidin-2-yl}nitramide → 2-[4-(3-Amino-2-pyridyl)butylamino]-5-(3-pyridylmethyl)-4-pyrimidone

HRID 1248318Notes

Reaction equation

HRID 1248318 reaction equation
[N+]([NH:4][C:5]1[NH:10][C:9](=[O:11])[C:8]([CH2:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)=[CH:7][N:6]=1)([O-])=O.[NH2:19][C:20]1[C:21]([CH2:26][CH2:27][CH2:28][CH2:29]N)=[N:22][CH:23]=[CH:24][CH:25]=1>>[NH2:19][C:20]1[C:21]([CH2:26][CH2:27][CH2:28][CH2:29][NH:4][C:5]2[NH:10][C:9](=[O:11])[C:8]([CH2:12][C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)=[CH:7][N:6]=2)=[N:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 12788688N-{6-Oxo-5-[(pyridin-3-yl)methyl]-1,6-dihydropyrimidin-2-yl}nitramideHCID 133508382-(4-Aminobutyl)pyridin-3-amine

Product 1

HCID 202792842-[4-(3-Amino-2-pyridyl)butylamino]-5-(3-pyridylmethyl)-4-pyrimidone

Procedure

Using a procedure similar to that of Example 16, 2-nitroamino-5-(3-pyridylmethyl)-4-pyrimidone was reacted with 1.1 molar equivalents of 4-(3-amino-2-pyridyl)butylamine, to give 2-[4-(3-amino-2-pyridyl)butylamino]-5-(3-pyridylmethyl)-4-pyrimidone, m.p. 130°-1.5°.

Sources & evidence

ORD record
ord-12b96db0ced9482ca890de6a99742768
Source dataset
uspto-grants-1985_06
Patent number
US04523015

Reaction notes

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