反应详情

3.0 g of 4-(α-hydroxybenzyl)-5-hydroxybenzocyclobutene-1-carboxylic acid are dissolved in 30 ml of dichloromethane and over a period of 10 minutes, while stirring, 30 g of pyridinium dichromate in 100 ml of dichloromethane are added dropwise thereto. Stirring is then carried out for 7 hours at room temperature, and the mixture is decanted off from the black residue, filtered over silica gel, concentrated to dryness by evaporation and crystallised from ether/hexane. 4-benzoyl-5-hydroxybenzocyclobutene-1-carboxylic acid is obtained having a melting point of 167°-169°.

1. stirringStirring
2. customthe mixture is decanted off from the black residue
3. filtrationfiltered over silica gel
4. concentrationconcentrated to dryness by evaporation
5. customcrystallised from ether/hexane