Ammonia → HCID 20279438, compound

Participants

Reaction Steps

Over a period of 15 minutes, 4.86 g of 4-(2,6-dichlorobenzoyl)-5-hydroxybenzocyclobutene-1-carboxylic acid chloride are added dropwise, while stirring, to 15 ml of a 2.5 % solution of ammonia in dichloromethane. Stirring is carried out for 7 hours at room temperature, small amounts of a finely crystalline precipitate are filtered off and the filtrate is concentrated to dryness by evaporation, chromatographed over silica gel using dichloromethane/methanol (15:1) as eluant and recrystallised from ether/hexane. 4-(2,6-dichlorobenzoyl)-5-hydroxybenzocyclobutene-1-carboxamide is obtained having a melting point of 174°.

Provenance & Evidence