Hydrochloric Acid → HCID 178496930, compound

Participants

Reaction Steps

5.0 g of 4-(o-fluorobenzoyl)-5-methoxybenzocyclobutene-1-carboxylic acid methyl ester are dissolved in 100 ml of dichloromethane; 6.4 g of aluminium trichloride are added and the whole is heated at boiling for 4 hours while stirring. The mixture is poured onto ice; 20 ml of concentrated hydrochloric acid are added and the whole is extracted by shaking twice with 100 ml of dichloromethane each time. The organic phases are combined, washed with water, dried over magnesium sulphate and concentrated to dryness by evaporation. The residue is chromatographed over silica gel and recrystallised from ether/hexane. 4-(o-fluorobenzoyl)-5-hydroxybenzocyclobutene-1-carboxylic acid methyl ester is obtained having a melting point of 72°-73°.

Provenance & Evidence