Water → 5-Benzoyloxybenzocyclobutene-1-carboxylic acid methyl ester

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Reaction Steps

27 g of 5-hydroxybenzocyclobutene-1-carboxylic acid methyl ester are dissolved in 2000 ml of dichloromethane and then 18 g of triethylamine are added. Over a period of 5 minutes, while stirring at 10°-20°, 25 g of benzoyl chloride are added in portions, stirring is carried out for 5 hours at room temperature, 200 ml of water are added and the organic phase is separated off, dried over magnesium sulphate and concentrated to dryness by evaporation. 5-benzoyloxybenzocyclobutene-1-carboxylic acid methyl ester is obtained in the form of a colourless, viscous oil.

Provenance & Evidence