5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → HCID 20277866, compound

HRID 1248408Notes

Reaction equation

HRID 1248408 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:19]=[CH:20][CH:21]=1)[O:7][CH2:8][CH2:9][C:10]1[C:11](=[O:18])[NH:12][C:13](SC)=[N:14][CH:15]=1.[NH2:22][CH2:23][CH2:24][S:25][CH2:26][C:27]1[O:31][C:30]([CH2:32][N:33]([CH3:35])[CH3:34])=[CH:29][CH:28]=1>>[CH3:35][N:33]([CH2:32][C:30]1[O:31][C:27]([CH2:26][S:25][CH2:24][CH2:23][NH:22][C:13]2[NH:12][C:11](=[O:18])[C:10]([CH2:9][CH2:8][O:7][C:6]3[CH:19]=[CH:20][CH:21]=[C:4]([CH2:3][O:2][CH3:1])[CH:5]=3)=[CH:15][N:14]=2)=[CH:28][CH:29]=1)[CH3:34]

Participants

3

Reactant 2

HCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 20277870HCID 20277870, compound

Product 1

HCID 20277866HCID 20277866, compoundYield 50.9%

Procedure

A mixture of 5-[2-[3-(methoxymethyl)phenoxy]ethyl]-2-(methylthio)-4(3H)-pyrimidinone (0.7 g ) and 5-[[(2-aminoethyl)thio]methyl]-N,N-dimethyl-2-furanmethanamine (0.54 g) was heated at 140° for 2 h. The residue was chromatographed (silica/methanol) to give the title compound (0.55 g) as a pale yellow oil.

Workup

  1. temperaturewas heated at 140° for 2 h
  2. customThe residue was chromatographed (silica/methanol)

Sources & evidence

ORD record
ord-45a9ed37b7044d83b23accd6f309ec03
Source dataset
uspto-grants-1985_06
Patent number
US04524071

Reaction notes

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