5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → HCID 20277876, compound

HRID 1248410Notes

Reaction equation

HRID 1248410 reaction equation
CS[C:3]1[NH:8][C:7](=[O:9])[C:6]([O:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[CH:5][N:4]=1.[NH2:17][CH2:18][CH2:19][S:20][CH2:21][C:22]1[O:26][C:25]([CH2:27][N:28]([CH3:30])[CH3:29])=[CH:24][CH:23]=1>>[CH3:30][N:28]([CH2:27][C:25]1[O:26][C:22]([CH2:21][S:20][CH2:19][CH2:18][NH:17][C:3]2[NH:8][C:7](=[O:9])[C:6]([O:10][C:11]3[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=3)=[CH:5][N:4]=2)=[CH:23][CH:24]=1)[CH3:29]

Participants

3

Reactant 2

HCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 20277851HCID 20277851, compound

Product 1

HCID 20277876HCID 20277876, compoundYield 49.7%

Procedure

A mixture of 2-(methylthio)-5-(3-pyridinyloxy)-4(3H)-pyrimidinone (1.18 g) and 5-[[(2-aminoethyl)thio]methyl]-N,N-dimethyl-2-furanmethanamine (2.14 g) was heated at 140° for 6 h. the residue was chromatographed (silica/ethyl acetate-methanol, 1:1) to give the title compound (1.0 g) as a yellow gum.

Workup

  1. temperaturewas heated at 140° for 6 h. the residue
  2. customwas chromatographed (silica/ethyl acetate-methanol, 1:1)

Sources & evidence

ORD record
ord-e91f89ee2252456cbef0087ea9cdce80
Source dataset
uspto-grants-1985_06
Patent number
US04524071

Reaction notes

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