Methanesulfonic Acid → HCID 86740155, compound

Participants

Reaction Steps

A solution of methanesulphonic acid (86 g), 5-[(dimethylamino)methyl]-2-furanmethanol (15.52 g), and 4-aminobutanol (17.82 g) in tetrahydrofuran (100 ml) was heated at 98°-100° for 1.5 h. After 1 h. at room temperature, excess anhydrous sodium carbonate was added and the suspension filtered after 18 h. The filtrate was evaporated, water (230 ml) added and the suspension extracted with ether (3×80 ml). The ethereal extracts were washed with water (2×50 ml), the aqueous fraction acidified with oxalic acid (25 g) and evaporated to low bulk. Excess anhydrous sodium carbonate and ethyl acetate (200 ml) were added, the suspension heated at boiling for 30 min. and the suspension filtered after 2 h. Evaporation of the filtrate yielded an oil which was distilled (100°-110°/0.08 mm) to give the title compound (6.64 g).

Provenance & Evidence