反应详情

A solution 3-(3-quinolinyl)propanoic acid (4.4 g) and concentrated sulphuric acid (2 ml) in absolute ethanol (50 ml) was refluxed for 5 h. then, evaporated to dryness. Aqueous sodium bicarbonate (8%, 50 ml) was added, the mixture extracted with ether (2×100 ml) and the ethereal extracts dried (Na2SO4). Evaporation of the ether and distillation of the residual oil (150°/0.06 mm) gave the title compound (4.3 g).

1. customevaporated to dryness
2. additionAqueous sodium bicarbonate (8%, 50 ml) was added
3. extractionthe mixture extracted with ether (2×100 ml)
4. dry with materialthe ethereal extracts dried (Na2SO4)
5. customEvaporation of the ether and distillation of the residual oil (150°/0.06 mm)