Methyl iodide → HCID 14338587, compound

HRID 1248414Notes

Reaction equation

HRID 1248414 reaction equation
[CH3:1]I.[N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[C:5]([CH2:13][C:14]2[C:15](=[O:21])[NH:16][C:17](=[S:20])[NH:18][CH:19]=2)[CH:4]=1.[OH-].[K+]>C(O)C>[CH3:1][S:20][C:17]1[NH:16][C:15](=[O:21])[C:14]([CH2:13][C:5]2[CH:4]=[N:3][C:12]3[C:7]([CH:6]=2)=[CH:8][CH:9]=[CH:10][CH:11]=3)=[CH:19][N:18]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 14338582HCID 14338582, compound

Product 1

HCID 14338587HCID 14338587, compoundYield 98.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl iodide (0.56 g) was added to a stirred solution of 1,2-dihydro-5-[(3-quinolinyl)methyl]-2-thioxo-4(3H)-pyrimidinone (1.2 g) and potassium hydroxide (0.23 g) in aqueous ethanol (50%, 20 ml) at 60°. After 30 min., the solution was cooled and the solid which separated was crystallised from aqueous ethanol to give the title compound (1.1 g), m.p. 220°-221°.

Workup

  1. temperaturethe solution was cooled
  2. customthe solid which separated
  3. customwas crystallised from aqueous ethanol

Sources & evidence

ORD record
ord-cef6cedffada41f0bfd80bb02f266653
Source dataset
uspto-grants-1985_06
Patent number
US04524071

Reaction notes

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