3-(3-(Piperidin-1-ylmethyl)phenoxy)propan-1-amine → HCID 54310514, compound

Participants

Reaction Steps

A mixture of 2-(methylthio)-5-(3-phenylpropyl)-4(3H)-pyrimidinone (0.52 g) and 3-[3-[(1-piperidinyl)methyl]phenoxy]propanamine (1.056 g) was heated at 140° for 4 h. The residue was chromatographed (silica/methanol-ethyl acetate 1:1) and the oily product titrated with light petroleum (b.p. 60°-80°) to give the title compound (0.18 g), m.p. 104°-108°.

Provenance & Evidence