Sulfuric Acid → HCID 178424048, compound

HRID 1248437Notes

Reaction equation

HRID 1248437 reaction equation
OS(O)(=O)=O.[S:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[C:11]1[N:12]=[CH:13][NH:14][C:15]=1[C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=1.O[CH2:24][N:25]1[C:29](=[O:30])[C:28]2=[CH:31][CH:32]=[CH:33][CH:34]=[C:27]2[C:26]1=[O:35]>C(O)(=O)CC>[C:26]1(=[O:35])[N:25]([CH2:24][C:10]2[S:6][C:7]([C:11]3[N:12]=[CH:13][NH:14][C:15]=3[C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)=[CH:8][CH:9]=2)[C:29](=[O:30])[C:28]2=[CH:31][CH:32]=[CH:33][CH:34]=[C:27]12

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 8354N-(hydroxymethyl)phthalimideHCID 178424049HCID 178424049, compound

Product 1

HCID 178424048HCID 178424048, compound

Reagents, catalysts & solvents 1

HCID 1032Propionic AcidSolvent

Procedure

375 ml of concentrated H2SO4 are added dropwise to a solution of 240 g of 4-(2-thienyl)-5-p-tolyl imidazole (1 mol) in 1,000 ml of propionic acid at 0° C., and 265 g (1.5 mol) of N-hydroxymethyl-phthalimide are added portionwise. The reaction mixture is left at 25° C. for 24 hours with stirring and the resulting suspension is poured out onto 400 g of ice. The precipitate obtained is suction filtered, washed with water, taken up with ammonia (10%) and again suction-filtered.

Workup

  1. customThe precipitate obtained
  2. washwashed with water
  3. filtrationagain suction-filtered

Sources & evidence

ORD record
ord-7c42cb3a35054896a6fac08624fd77e4
Source dataset
uspto-grants-1985_06
Patent number
US04524123

Reaction notes

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