Ethyl 4-Chloroquinoline-3-carboxylate → HCID 178515192, compound

Participants

Reaction Steps

A solution of 2.36 g of ethyl 4-chloroquinoline-3-carboxylate and 1.46 g of 2-hydrazinopyrimidine in 80 ml of ethanol is refluxed for 2 hours and 30 minutes. The resulting slurry is cooled down to 5°, then filtered and the resulting product is taken up in 20 ml of N sodium hydroxide and sufficient water to effect solution. Ammonium chloride (10 g) is added, the resulting precipitate is collected, and is washed three times with ethanol and three times with ether to yield 2-(2-pyrimidyl)-pyrazolo[4,3-c]quinolin-3(5H)-one, m.p. above 360°; IR (KBr) 800, 817, 844, 886 cm-1.

Provenance & Evidence