反应详情

A solution of 2.0 of ethyl 4-chloro-6-fluoroquinolin-3-carboxylate and 0.95 g of 2-hydrazinopyrimidine in 40 ml of 95% ethanol is heated under reflux for 16 hours. The reaction mixture is filtered and the resulting solid is taken up in 20 ml of N sodium hydroxide and sufficient water to effect solution. Ammonium chloride (10.7 g) is added, the resulting precipitate is collected, washed with water and dried to yield 8-fluoro-2-(2-pyrimidyl)-pyrazolo[4,3-c]quinolin-3(5H)-one, as a hydrate, m.p. above 350°; IR (KBr) 800, 829, 870, 880 cm-1.

1. temperatureunder reflux for 16 hours
2. filtrationThe reaction mixture is filtered
3. additionAmmonium chloride (10.7 g) is added
4. customthe resulting precipitate is collected
5. washwashed with water
6. customdried