HCID 86740156, compound → HCID 178515193, compound

HRID 1248451Notes

Reaction equation

HRID 1248451 reaction equation
Cl.[S:2]1[CH:6]=[CH:5][N:4]=[C:3]1[NH:7][NH:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]=[CH:11][C:10]=1[C:19]([O:21]CC)=O>C(O)CCC>[S:2]1[CH:6]=[CH:5][N:4]=[C:3]1[N:7]1[C:19](=[O:21])[C:10]2=[CH:11][NH:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=3[C:9]2=[N:8]1

Participants

3

Reactant 1

HCID 86740156HCID 86740156, compound

Product 1

HCID 178515193HCID 178515193, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of ethyl 4-(2-thiazolylhydrazino)-quinoline-3-carboxylate hydrochloride (1.16 g) and 20 ml of n-butanol is heated under reflux for 5 hours, cooled to room temperature and filtered. The resulting solid is washed with ethanol and ether, and dried to yield 2-(2-thiazolyl)-pyrazolo[4,3-c]quinolin-3(5H)-one, m.p. over 350°; IR (KBr) 818, 840, 871, 891 cm-1.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 5 hours
  3. filtrationfiltered
  4. washThe resulting solid is washed with ethanol and ether
  5. customdried

Sources & evidence

ORD record
ord-6fd040c380124411a5e4aaf9855b8545
Source dataset
uspto-grants-1985_06
Patent number
US04524146

Reaction notes

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