Diethyl Ether → HCID 86740156, compound

Participants

Reaction Steps

A solution of 1.63 g of ethyl 4-chloroquinoline-3-carboxylate and 0.80 g of 2-hydrazinothiazole in 22 ml of methanol is stirred for 26 hours at 23°; 22 ml of diethyl ether is added to the resulting slurry, which is then filtered. The precipitate is washed once with methanol-ether (1:1) and once with ether to yield ethyl 4-(2-thiazolylhydrazino)-quinoline-3-carboxylate hydrochloride as a yellow solid which is used directly in the above cyclization.

Provenance & Evidence