HCID 2804638, compound → 5-acetyl-6-methyl-2(1H)-pyridinone
Reaction equation
[C:1]([C:4]1[CH2:5][CH2:6][C:7](=[O:11])[NH:8][C:9]=1[CH3:10])(=[O:3])[CH3:2]>[Pd]>[C:1]([C:4]1[CH:5]=[CH:6][C:7](=[O:11])[NH:8][C:9]=1[CH3:10])(=[O:3])[CH3:2]Participants
3
Reagents, catalysts & solvents 1
Procedure
Kato et al. [J. Heterocyclic Chem. 18, 603-606 (1981)] show, inter alia, the dehydrogenation of 5-acetyl-3,4-dihydro-6-methyl-2(1H)-pyridinone by heating it with palladium black to produce 5-acetyl-6-methyl-2(1H)-pyridinone, which in turn is reacted with phosphorus oxychloride (phosphoryl chloride) to produce a mixture of 6-chloro-3-ethynyl-2-methylpyridine and 6-chloro-3-(1-chlorovinyl)-2-methylpyridine.
Sources & evidence
- ORD record
- ord-f045eb0c1553463899688c5acbe10d0f
- Source dataset
- uspto-grants-1985_06
- Patent number
- US04524149
Reaction notes
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