HCID 131714247, compound → HCID 13531538, compound

Participants

Reaction Steps

A mixture of 1-[(5S,2R)-5-(benzoyloxy)-2-methyl-1,4-dioxo-6-phenylhexyl]-L-proline, phenylmethyl ester (230 mg., 0.435 mmole) and 10% palladium on carbon catalyst (50 mg.) in ethyl acetate (15 ml.) is stirred under hydrogen gas for 4 hours. The resulting mixture is filtered (millipore) and the filtrate concentrated to give the desired product as a colorless solid which is then dried under vacuum over P2O5 to give 144 mg. of 1-[(5S,2R)-5-(benzoyloxy)-2-methyl-1,4-dioxo-6-phenylhexyl]-L-proline; m.p. 130°-134°; [α]D20 =-110° (c=1.09, pyridine); Rf =0.37 [silica gel, ethyl acetate:pyridine:acetic acid; water (180:20:6:11)].

Provenance & Evidence