HCID 54509558, compound → 4-{4-[2-Chloro-4-(trifluoromethyl)phenoxy]phenoxy}pent-1-en-3-one

HRID 1248539Notes

Reaction equation

HRID 1248539 reaction equation
[Cl:1][C:2]1[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[CH:20][C:3]=1[O:4][C:5]1[CH:19]=[CH:18][C:8]([O:9][CH:10]([CH3:17])[C:11]([O:15]C)=[CH:12][CH2:13]O)=[CH:7][CH:6]=1>C(Cl)Cl>[Cl:1][C:2]1[CH:23]=[C:22]([C:24]([F:25])([F:27])[F:26])[CH:21]=[CH:20][C:3]=1[O:4][C:5]1[CH:19]=[CH:18][C:8]([O:9][CH:10]([CH3:17])[C:11](=[O:15])[CH:12]=[CH2:13])=[CH:7][CH:6]=1

Participants

3

Reactant 1

HCID 54509558HCID 54509558, compound

Product 1

HCID 202524304-{4-[2-Chloro-4-(trifluoromethyl)phenoxy]phenoxy}pent-1-en-3-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The foregoing alcohol (380 mg) is reacted with 35% HClO4 (4 ml) in CH2Cl2 (4 ml) at RT for 24 hours. The mixture is then extracted with CH2Cl2 and the combined extracts washed, dried and concentrated to dryness. The product is purified by prep. thin layer chromatography to give 4-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]-3-oxo-1-pentene, MS m/e 396 (M+).

Workup

  1. extractionThe mixture is then extracted with CH2Cl2
  2. washthe combined extracts washed
  3. customdried
  4. concentrationconcentrated to dryness
  5. customThe product is purified by prep

Sources & evidence

ORD record
ord-ea41e2ca81f14990b8b1f02b34bf627b
Source dataset
uspto-grants-1985_06
Patent number
US04525205

Reaction notes

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