Ethanol → HCID 45086650, compound

HRID 1248549Notes

Reaction equation

HRID 1248549 reaction equation
[NH2:1][C@H:2]([C:4]([OH:6])=[O:5])[CH3:3].[CH3:7][C:8]([CH2:10][CH3:11])=O.C(O)C>O.[Pd]>[CH:8]([NH:1][C@H:2]([C:4]([OH:6])=[O:5])[CH3:3])([CH2:10][CH3:11])[CH3:7]

Participants

6

Reactant 3

HCID 702EthanolHCID 5950L-AlanineHCID 6569Methyl Ethyl Ketone

Product 1

HCID 45086650HCID 45086650, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent2×

Procedure

356 g of alanine (4 mols) is dissolved in 1.5 liters of deionized water and put into a 1-gallon autoclave. 25 g of 10% Pd on carbon, wet with water, 423 g of methylethylketone (5.85 mols) and 250 ml of ethanol are added. The autoclave is closed and hydrogenation is carried out at 90°-105° C. and 63.3-77.3 kg/cm2. A pressure drop corresponding to 83.3 kg/cm2 is observed in the course of 4 hours. The autoclave is allowed to cool overnight.

Workup

  1. customThe autoclave is closed
  2. customis carried out at 90°-105° C.
  3. customis observed in the course of 4 hours
  4. temperatureto cool overnight

Sources & evidence

ORD record
ord-4eab54c54c4c4043917e56e8872fc2b3
Source dataset
uspto-grants-1985_06
Patent number
US04525294

Reaction notes

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