Methyl iodide → HCID 20277052, compound

Participants

Reaction Steps

6-Fluoro-3-(4'-fluorophenyl)-1-hydroxy-1-pyrid-4-ylindane (5.0 g) was reacted with methyliodide as described in Example 2, and the resulting pyridylium iodide (viscous oil) was dissolved in ethanol (150 ml) and 0.5 g PtO2 added. The estimated amount of hydrogen was consumed in 3 hrs. (3.0-3.5 atm.). The catalyst was filtered off and the ethanol evaporated. Ice-cold NaOH solution (100 ml 0.2M) was added to the residue and the resulting base extracted with ethyl acetate (2×50 ml). The combined organic phases were dried (MgSO4) and the solvent evaporated. The remaining oil was dissolved in isopropylether, and by cooling the product precipitated and was filtered off. Yield: 4.7 g (88.8%) of the title compound. MP: 146°-147° C.

Provenance & Evidence