HCID 53891176, compound → HCID 54299948, compound

HRID 1248628Notes

Reaction equation

HRID 1248628 reaction equation
C([O:3][CH2:4][CH2:5][CH2:6][S:7]([N:10]1[CH2:15][CH2:14][CH2:13][S:12][C:11]1=[CH:16][N+:17]([O-:19])=[O:18])(=[O:9])=[O:8])=O>ClCCl.CO>[OH:3][CH2:4][CH2:5][CH2:6][S:7]([N:10]1[CH2:15][CH2:14][CH2:13][S:12][C:11]1=[CH:16][N+:17]([O-:19])=[O:18])(=[O:8])=[O:9]

Participants

4

Reactant 1

HCID 53891176HCID 53891176, compound

Product 1

HCID 54299948HCID 54299948, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

2 g of 1 was elected through a column of 200 g of neutral alumina, using a 19:1 v:v mixture of dichloromethane and methanol as eluent. The fractions containing 2 were stripped of solvent under reduced pressure and the combined residue was triturated with ether, to give 2, as a solid, m.p.: 80°-83° C.

Workup

  1. additionThe fractions containing 2
  2. customthe combined residue was triturated with ether
  3. customto give 2

Sources & evidence

ORD record
ord-4e800ecdec0c48bd948b67cfd7430214
Source dataset
uspto-grants-1985_06
Patent number
US04525474

Reaction notes

Loading…