反应详情

A mixture of 1.0 g of N-ethyl-N-(3-pyrazolo[1,5-a]pyrimidin-7-ylphenyl)acetamide and 4.57 g of 1-chlorobenzotriazole in 50 ml of dichloromethane was refluxed for 25 minutes, then cooled and poured into 50 ml of ice-cold 2.5N aqueous sodium hydroxide. The mixture was filtered through hydrous magnesium silicate, precipitated with hexane and the solid collected, giving 0.7 g of the desired product, mp 157°-159°C.

1. temperaturewas refluxed for 25 minutes
2. temperaturecooled
3. filtrationThe mixture was filtered through hydrous magnesium silicate
4. customprecipitated with hexane
5. customthe solid collected