Methyl iodide → HCID 54476646, compound

HRID 1248809Notes

Reaction equation

[CH3:1][N:2]([CH3:20])[CH:3]=[CH:4][C:5]([C:7]1[CH:8]=[C:9]([NH:13][C:14]([CH:16]2[CH2:19][CH2:18][CH2:17]2)=[O:15])[CH:10]=[CH:11][CH:12]=1)=[O:6].[CH3:21]I>>[CH3:20][N:2]([CH3:1])[CH:3]=[CH:4][C:5]([C:7]1[CH:8]=[C:9]([N:13]([CH3:21])[C:14]([CH:16]2[CH2:19][CH2:18][CH2:17]2)=[O:15])[CH:10]=[CH:11][CH:12]=1)=[O:6]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 53797197HCID 53797197, compound

Product 1

HCID 54476646HCID 54476646, compound

Procedure

This compound was then converted to N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]cyclobutanecarboxamide, mp 155°-157° C., by the procedure of Example 1 and further alkylated by the procedure of Example 6, using methyl iodide to give 8.32 g of N-[3-[3-(dimethylamino)1-oxo-2-propenyl]phenyl]-N-methylcyclobutanecarboxamide, mp 117°-119° C.

Sources & evidence

ORD record: ord-258971c8e443418aacebcdc3ef45828a
Source dataset: uspto-grants-1986_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04626538

Reaction notes

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