Methyl iodide → HCID 178503994, compound

HRID 1248815Notes

Reaction equation

HRID 1248815 reaction equation
[CH3:1][I:2].[F:3][C:4]([F:16])([F:15])[C:5]1[CH:6]=[C:7]([NH:11][C:12]([NH2:14])=[S:13])[CH:8]=[CH:9][CH:10]=1>O1CCOCC1>[IH:2].[F:16][C:4]([F:3])([F:15])[C:5]1[CH:6]=[C:7]([NH:11][C:12](=[NH:14])[S:13][CH3:1])[CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 7358443-(Trifluoromethyl)phenylthiourea

Product 1

HCID 178503994HCID 178503994, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

The starting material for this synthesis is produced as follows: 8 g of methyl iodide in 20 ml of dioxane is added to a solution of 11 g of N-(m-trifluoromethylphenyl)thiourea in 30 ml of dioxane. The reaction mixture is heated for 3 hours on a water bath. The dioxide is evaporated off under reduced pressure, and the residue is recrystallised from a mixture of isopropanol and ethyl acetate to yield N-(m-trifluoromethylphenyl)-S-methylisothiourea-hydroiodide, which melts at 220°.

Workup

  1. customThe starting material for this synthesis is produced
  2. temperatureThe reaction mixture is heated for 3 hours on a water bath
  3. customThe dioxide is evaporated off under reduced pressure
  4. customthe residue is recrystallised from a mixture of isopropanol and ethyl acetate

Sources & evidence

ORD record
ord-7daf8aef9f6747369b4c3a2b44bbf76f
Source dataset
uspto-grants-1986_12
Patent number
US04626537

Reaction notes

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