反应详情

The starting material for this synthesis is produced as follows: 8 g of methyl iodide in 20 ml of dioxane is added to a solution of 11 g of N-(m-trifluoromethylphenyl)thiourea in 30 ml of dioxane. The reaction mixture is heated for 3 hours on a water bath. The dioxide is evaporated off under reduced pressure, and the residue is recrystallised from a mixture of isopropanol and ethyl acetate to yield N-(m-trifluoromethylphenyl)-S-methylisothiourea-hydroiodide, which melts at 220°.

1. customThe starting material for this synthesis is produced
2. temperatureThe reaction mixture is heated for 3 hours on a water bath
3. customThe dioxide is evaporated off under reduced pressure
4. customthe residue is recrystallised from a mixture of isopropanol and ethyl acetate