Hydrochloric Acid → HCID 20226079, compound

Participants

Reaction Steps

8.3 g (29 mMol) of E-1-(5-t-butoxycarbonylamino-1,2,4-thiadiazol-3-yl)propene-1-carboxylic acid were dissolved in 40 ml of DMF and the solution was added to a solution of 10 g of potassium t-butylate in 30 ml of DMF at 0° C., whereupon the internal temperature rose to 30° C. The mixture was stirred for 15 minutes, 300 ml of water were poured in and the pH was adjusted to 2 with 1N HCl. The mixture was extracted 2×ethyl acetate and the combined organic phases were washed with water, dried over MgSO4 and evaporated in vacuo. 8.0 g (96%) of E/Z mixture~1:2.

Provenance & Evidence