Hydrochloric Acid → HCID 70453831, compound

Participants

Reaction Steps

A solution of N-formyl, N-(1-carbethoxy-3-phenylpropyl)(L)-alanyl(S)-2-(2-acetoxy-1-oxoethyl)-pyrrolidine (460 mg; 1 mmol) in 5 ml of 5% ethanolic hydrochloric acid (5.5 ml of 38% aqueous HCl in 60 ml of ethanol) can be kept at 25° for 2 days. It can then be concentrated under reduced pressure and the residue triturated with ether to give N-(1-carbethoxy-3-phenylpropyl)(L)-alanyl (S)-2-(2-hydroxy-1-oxoethyl)-pyrrolidine hydrochloride.

Provenance & Evidence