2-Fluorophenol → HCID 13563908, compound

Participants

Reaction Steps

100 g (0.9 mole) of 2-fluorophenol and 477 g (2.7 moles) of trans-1,4-dibromobut-2-ene were stirred under reflux with 70 g of K2CO3 in 500 ml of acetone for 5 hours. The mixture was filtered, and acetone was evaporated off under reduced pressure, the residue was taken up in methylene chloride, the solution was washed four times with aqueous 1 N NaOH solution, and the methylene chloride phase was dried with sodium sulfate and freed from unreacted 1,4-dibromobutene under reduced pressure. 175 g of trans-1-(2-fluorophenoxy)-4-bromobut-2-ene remained.

Provenance & Evidence