Chloroform → HCID 13588342, compound

Participants

Reaction Steps

A solution of 25 g of p-butoxyaniline and 17.85 g of 2,6-dichloro-3-nitrobenzoic acid in 50 ml of N,N-dimethylaniline was heated under nitrogen at 100° for 18 hours. The reaction mixture was treated with 500 ml of 0.2N sodium hydroxide and 500 ml of chloroform. The aqueous layer was washed with additional chloroform and acidified to provide 2-[(4-butoxyphenyl)amino]-6-chloro-3-nitrobenzoic acid, mp 166°-169° C.

Provenance & Evidence