6-Methoxyquinoline → Quinoline, 1,2,3,4-tetrahydro-6-methoxy-

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Reaction Steps

A solution of 218.5 g. of 6-methoxyquinoline in 1750 ml of methanol was hydrogenated at 60 psi over 30 g. of platinum dioxide at 50° overnight. The reaction was filtered and the filtrate concentrated to give an oil. The oil was distilled to give 148.6 g. of 6-methoxy-1,2,3,4-tetrahydroquinoline (66% yield) boiling in the range 123°-125° C. at 8 Torr.

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