Propylethinylcarbinol → HCID 20226190, compound

Participants

Reaction Steps

40.2 G (0.41M) of 1-hexyn-3-ol in 200 ml of anhydrous tetrahydrofurane (THF) have been placed in a three-necked reaction vessel and cooled to -70°. At this temperature there were added under stirring 390 ml (0.91M) of a 15% solution of butyl-lithium in hexane and the temperature was then raised to about 20° within one night. A solution of 40 g (0.26M) of 2-ethyl-2,6-dimethylcyclohexanone in 90 ml of THF-75/25 isomeric mixture of the following compounds ##STR15## was added dropwise to the reaction mixture cooled again to -70°. After having been kept under stirring for 3 h at -70° and overnight at room temperature, the mixture was poured onto ice, extracted with ether, washed with brine until neutrality, dried over Na2SO4, filtered and concentrated.

Provenance & Evidence