HRID1248881

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(CBr)NC1C(=O)N2C(C(=O)O)=C(CNC(=O)c3c(Cl)cccc3Cl)CS[C@H]12

HCID14502350

未命名化合物

HCID178527830

未命名化合物

PRODUCTS

生成物

结构：O=C(CSc1nc(-c2ccccc2)cs1)NC1C(=O)N2C(C(=O)O)=C(CNC(=O)c3c(Cl)cccc3Cl)CS[C@H]12

HCID14502356

未命名化合物

收率 62%

PROCEDURE

实验过程

1.0 g. of 7-bromoacetamido-3-(2,6-dichlorobenzoylamino)methylceph-3-em-4-carboxylic acid and 0.39 g. of 2-mercapto-4-phenyl-1,3-thiazole were reacted and worked up according to the method of Example 15. Thus 0.78 g. o(62%) of 7-(4-phenyl-1,3-thiazole-2-ylthio)acetamido-3-(2,6-dichlorobenzoylamino)methylceph-3-em-4-carboxylic acid were obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6291d096d11446bea1bd34f6ac21e5a5
来源数据集: uspto-grants-1986_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04626533
来源说明: uspto-grants-1986_12

反应 SMILES

Br[CH2:2][C:3]([NH:5][CH:6]1[C:28](=[O:29])[N:8]2[C:9]([C:25]([OH:27])=[O:26])=[C:10]([CH2:13][NH:14][C:15](=[O:24])[C:16]3[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=3[Cl:23])[CH2:11][S:12][C@H:7]12)=[O:4].[SH:30][C:31]1[S:32][CH:33]=[C:34]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[N:35]=1>>[C:36]1([C:34]2[N:35]=[C:31]([S:30][CH2:2][C:3]([NH:5][CH:6]3[C:28](=[O:29])[N:8]4[C:9]([C:25]([OH:27])=[O:26])=[C:10]([CH2:13][NH:14][C:15](=[O:24])[C:16]5[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=5[Cl:23])[CH2:11][S:12][C@H:7]34)=[O:4])[S:32][CH:33]=2)[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1