Sodium Carbonate → HCID 13292182, compound

Participants

Reaction Conditions

Reaction Steps

13.5 parts of 2-methyl-3-(4-triethylsilylphenyl)-propyl chloride and 16.5 parts of cis-2,6-dimethylmorpholine were mixed and the mixture was stirred at 150° C. for 6 hours, cooled and brought to about pH 9 with saturated Na2CO3 solution. After extraction with methylene chloride, the organic phase was dried and concentrated and the residue was distilled to give, at a boiling point of 110°-114° C./0.01 mm Hg, 12.6 parts of 4-[3-(4-triethylsilylphenyl)-2-methylpropyl]-cis-2,6-dimethylmorpholine of nD23 1.5025 (Compound No. 15).

Provenance & Evidence