Phosgene → N-(5,7-dichloro-2,3-dihydrobenzofuran-2-ylmethyl)-N-butylcarbamyl chloride

Participants

Reaction Steps

A thoroughly stirred suspension of 26 g (0.0838 mole) of N-(5,7-dichloro-2,3-dihydrobenzofuran-2-ylmethyl)-N-butylamine hydrochloride in 250 ml of dry ethyl acetate was gassed with phosgene at 50° C. After 4 hours, the suspended material had dissolved. The mixture was evaporated down under reduced pressure, at 50° C. and under 0.5 mbar in the final stage. 27 g of N-(5,7-dichloro-2,3-dihydrobenzofuran-2-ylmethyl)-N-butylcarbamyl chloride were obtained as a colorless oil, which was reacted further without additional purification.

Provenance & Evidence