Sodium ethoxide → HCID 178493646, compound

Participants

Reaction Steps

The crude 4-(3',5'-difluoro-4'-methoxybenzyl)-1-formyl-3-thiosemicarbazide (7.3 g) was refluxed overnight in a solution of sodium ethoxide (from sodium (0.3 g) in ethanol (25 ml). The reaction was filtered, evaporated to dryness, and diluted with water. The aqueous solution was acidified to pH 3-4 with 10% hydrochloric acid, and the precipitate was collected by filtration and recrystallized from ethanol-hexane to yield 4.4 g (65%) of 4-(3',5'-difluoro-4'-methoxybenzyl)-1,2,4-triazole-3-thiol, m.p.: 124°-126° C.

Provenance & Evidence