反应详情

A mixture of 3.5 g. of methyl 2-phenylamino-3pyrazine carboxylate, 30 ml. of ethyl caproate and 4 g. of potassium tertiary butoxide is stirred and heated under nitrogen at 150°-160° for one and a half hours. The reaction mixture is poured on ice, extracted with ethyl acetate and the ethyl acetate extracts washed with water. The combined aqueous layers are acidified to pH 5.5 with dilute hydrochloric acid and the solid filtered. Recrystallization from ethyl acetate-hexane yields the product of this example as a colorless solid; m.p. 183°-185° C.

1. additionA mixture of 3.5 g
2. temperatureheated under nitrogen at 150°-160° for one and a half hours
3. additionThe reaction mixture is poured on ice
4. extractionextracted with ethyl acetate
5. washthe ethyl acetate extracts washed with water
6. filtrationthe solid filtered
7. customRecrystallization from ethyl acetate-hexane
8. customyields the product of this example as a colorless solid