Imidazole → HCID 13749943, compound

Participants

Reaction Steps

A mixture of 1-(2,4-dichlorophenyl)-2-(4-methylphenyl)propen-1-one (660 mg) and imidazole (770 mg) in ethanol (10 ml) were stirred at room temperature for 16 hours. The reaction mixture was concentrated under reduced pressure, dissolved in ethyl acetate, washed with water, dried over anhydrous magnesium sulphate and concentrated under reduced pressure to yield a gum. The gum was chromatographed on silica gel in methanol: dichloromethane (1:24) to yield 1-(2,4-dichlorophenyl)-3-(imidazol-1-yl)-2-(4-methylphenyl)propan-1-one (450 mg) (Found: C, 78.25; H, 5.88; N, 9.53; C19H18N2O requires C, 78.62; H, 6.21; N, 9.66) which was treated with ethereal hydrogen chloride to yield the hydrochloride salt of 1-(2,4-dichlorophenyl)-3-(imidazol-1-yl)-2-(4-methylphenyl)propan-1-one m.p. 92°-96° C. (Found: C, 54.79; H, 4.33; N, 6.59; C19H17Cl3N2O.H2O requires C, 55.16; H, 4.38; N, 6.77) having the formula: ##STR25##

Provenance & Evidence