反应详情

In a manner similar to that described in Example I, 30 grams isophorone in 57 grams aqueous acetic acid (35% H2O) was ozonized at ambient temperature and pressure in a 300 ml glass cylinder for approximately 5 1/2 hours. The resulting reaction product was then slowly dropped into a small amount of refluxing acetic acid, stripped at 140° C. under vacuum to remove water and acetic acid, and then vacuum distilled. Ninety-five percent yield of high purity 5-keto-3,3-dimethylhexanoic acid was obtained boiling in the range 96° C.-106° C. (0.1 mm Hg).

1. customwas ozonized at ambient temperature
2. customfor approximately 5 1/2 hours
3. customThe resulting reaction product
4. customstripped at 140° C. under vacuum
5. customto remove water and acetic acid
6. distillationvacuum distilled