HCID 178418361, compound → HCID 178462341, compound

Participants

Reaction Steps

BOC-Asp(OBzl)-Thr(Bzl)-Asp(OBzl)-Pro-Arg(NO2)-OBzl, was dissolved in a mixture of acetic acid (500 ml), water (500 ml), and methanol (3-5 liters). Palladium 10% on activated carbon (100-200 g) was added to the solution and hydrogen gas passed through the mixture for 20-40 hours. The catalyst was removed by filtration and the filtrate evaporated to dryness. The residue was triturated with ether (3-4 liters), and the resulting solid filtered to produce BOC-Asp-Thr-Asp-Pro-Arg. The yield was about 40-60%.

Provenance & Evidence