HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → HCID 13198946, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | (2s)-1,1-diphenylpropane-1,2-diol | HCID 736300 | — |
| Product | HCID 13198946 | HCID 13198946 | — |
Reaction Steps
By treating (S)-1,1-diphenyl-1,2-propanediol with mesyl chloride, (S)-2-methanesulfonyloxy-1,1-diphenyl-1-propanol was obtained. Namely, as a result of the treatment of (S)-1,1-diphenyl-1,2-propanediol with CH3SO2Cl (1.2 equivalent)-(C2H5)3 -N(1.5 equivalent) at 0° C. in CH2Cl2, (S)-2-methanesulfonyloxy-1,1-diphenyl-1-propanol was obtained in a yield of 87% (the position selectivity of this sulfonylation reaction was more than 95% from the measurement with 1H NMR).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04628120 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-89338acf20b34231be69b13207f4a2af |
| Source note | uspto-grants-1986_12 |