反应详情

In the same manner as described in Example 2, (i), (3RS)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (42.25 g), KOH (23.38 g), carbon disulfide (12.1 ml), methyl iodide (16.3 ml) and 50% ethanol (600 ml) are reacted. The product is crystallized from chloroform to give the title compound (50.2 g, 59%), m.p. 111°-113° C., NMR (CDCl3, δ): 2.68 (s, 3H, N--CSSCH3), Mass (m/e): 306 (M+), 258 (M+ --CH3SH).

1. customare reacted
2. customThe product is crystallized from chloroform