Ethanol → (3RS)-2-[(n-Butylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid

Participants

Reaction Steps

In the same manner as described in Example 6, (3RS)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (3.24 g), KOH (96%, 1.75 g), 50% ethanol (65 ml), carbon disulfide (0.91 ml) and n-butyl iodide (3.3 g) are reacted and treated. The product is crystallized from chloroform to give the title compound (1.9 g) as pale yellow crystals, m.p. 163°-164° C.

Provenance & Evidence