Water → HCID 13561926, compound

Participants

Reaction Steps

In the same manner as described in Example 6, (3RS)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (4.32 g), NaOH (1.65 g), water (2 ml), dimethylsulfoxide (24 ml), carbon disulfide (1.2 ml) and n-decyl bromide (5.31 g) are reacted and treated. The residue thus obtained is purified by silica gel column chromatography (solvent, chloroform:methanol:acetic acid=98:1:0.5) and then crystallized from n-hexane to give the title compound (4.8 g, 55%), m.p. 152.5°-154° C. (decomp.).

Provenance & Evidence