HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (3S)-2-[(Benzylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (3S)-1H,2H,3H,4H,9H-pyrido(3,4-b)indole-3-carboxylic acid | HCID 449440 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (3S)-2-[(Benzylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid | HCID 13561932 | 52.3% |
Reaction Steps
In the same manner as described in Example 16, (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (21.6 g), K2CO3 (13.8 g), water (550 ml), ethanol (550 ml), carbon disulfide (6 ml) and benzyl bromide (14 ml) are reacted and treated. The residue is purified by silica gel column chromatography (solvent, chloroform:methanol=10:1) to give the title compound (20 g, 52.3%) as powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04628057 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-e2dfa1bbd8234cb797eda786eac67703 |
| Source note | uspto-grants-1986_12 |