HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → (3S)-2-[(4-Chlorobenzylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | 1-Chloro-4-(chloromethyl)benzene | HCID 7723 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (3S)-1H,2H,3H,4H,9H-pyrido(3,4-b)indole-3-carboxylic acid | HCID 449440 | — |
| Product | (3S)-2-[(4-Chlorobenzylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid | HCID 13561935 | 69% |
Reaction Steps
In the same manner as described in Example 16, (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (1.08 g), 2N NaOH (5 ml), 50% ethanol (15 ml), carbon disulfide (0.3 ml) and 4-chlorobenzyl chloride (1.13 g) are reacted and treated. The product is crystallized from n-hexane to give the title compound (1.44 g, 69%), m.p. 139°-141° C. (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04628057 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-74bd839771bb42f5ab76ee0c3ba81abe |
| Source note | uspto-grants-1986_12 |