Carbon Disulfide → HCID 13859046, compound

HRID 1249053Notes

Reaction equation

HRID 1249053 reaction equation
[CH2:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH2:4][CH:3]([C:14]([OH:16])=[O:15])[NH:2]1.[OH-].[K+].[C:19](=[S:21])=[S:20].Cl.[N:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[CH2:29]Cl>C(O)C>[N:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[CH2:29][S:20][C:19]([N:2]1[CH:3]([C:14]([OH:16])=[O:15])[CH2:4][C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[NH:12][C:13]=2[CH2:1]1)=[S:21]

Participants

6

Reactant 4

HCID 6348Carbon DisulfideHCID 14797Potassium HydroxideHCID 23392Picolyl chloride hydrochlorideHCID 982851,2,3,4-Tetrahydro-Beta-Carboline-3-Carboxylic Acid

Product 1

HCID 13859046HCID 13859046, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the same manner as descsribed in Example 32, (3RS)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (3.24 g), KOH (1.75 g), carbon disulfide (0.91 ml), 50% ethanol (70 ml) and 2-pyridylmethyl chloride hydrochloride (2.95 g) are reacted and treated to give the title compound (2.07 g) as pale yellow powder.

Workup

  1. customare reacted
  2. additiontreated

Sources & evidence

ORD record
ord-e6e652974db741fba209b7f46ad8a20f
Source dataset
uspto-grants-1986_12
Patent number
US04628057

Reaction notes

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