HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Disulfide → (3R)-2-[(1-Naphthylmethylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | 1-Chloromethylnaphthalene | HCID 6845 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid | HCID 675102 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (3R)-2-[(1-Naphthylmethylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid | HCID 13561955 | — |
Reaction Steps
In the same manner as descsribed in Example 32, (3R)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (3.24 g), KOH (1.75 g), carbon disulfide (0.91 ml), 50% ethanol (70 ml) and 1-naphthylmethyl chloride (3.14 g) are reacted and treated to give the title compound (2.84 g) as pale yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04628057 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-b9ebcf9ffc554658b7f56ba76e42c372 |
| Source note | uspto-grants-1986_12 |