HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Disulfide → (3RS)-2-[(Phenethylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | Phenethyl bromide | HCID 7666 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1,2,3,4-Tetrahydro-Beta-Carboline-3-Carboxylic Acid | HCID 98285 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | (3RS)-2-[(Phenethylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid | HCID 13561956 | — |
Reaction Steps
In the same manner as descsribed in Example 32, (3RS)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (3.24 g), KOH (1.75 g), carbon disulfide (0.91 ml), dimethylsulfoxide (20 ml), water (5 ml) and phenethyl bromide (3.33 g) are reacted and treated. The product is crystallized from chloroform to give the title compound (2.77 g), m.p. 89°-90° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04628057 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-92c18c19ff1447fbb803e7be3664e4e6 |
| Source note | uspto-grants-1986_12 |