HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 86741150, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (1S,3S)-1-Ethyl-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid | HCID 178220 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86741150 | HCID 86741150 | 52.7% |
Reaction Steps
In the same manner as described in Example 43, (1RS,3RS)-cis-1-ethyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (1.22 g), triethylamine (1.21 g), carbon disulfide (456 mg), methyl iodide (852 mg), methanol (30 ml) and water (3 ml) are reacted and treated. The product is recrystallized from aqueous ethanol to give the title compound (880 mg, 52.7%) as colorless prisms, m.p. 198°-200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04628057 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-856050c2a3374b888053f9d24f0a78cd |
| Source note | uspto-grants-1986_12 |