HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Ethyl (3R)-2-[(methylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | ethyl (3R)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylate | HCID 7223904 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl (3R)-2-[(methylthio)thiocarbonyl]-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate | HCID 13561982 | — |
Reaction Steps
In the same manner as described in Example 53, ethyl (3R)-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (224 mg), triethylamine (120 mg), carbon disulfide (0.08 ml), ethanol (25 ml) and methyl iodide (0.08 ml) are reacted and treated. The product is crystallized from ether to give the title compound (140 mg) as colorless prisms, m.p. 139°-141° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04628057 |
| Source dataset | uspto-grants-1986_12 |
| ORD ID | ord-d3c976da8dd840d1903f027a69d3381b |
| Source note | uspto-grants-1986_12 |